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Computational methods


Computational Methods include useful new routines and algorithms with applications to Bioinformatics such as new sequence manipulation and analysis methods. Also included are new methods of computational analysis of biological data that facilitate data interpretation.


Citations 1-10 of 359 total displayed.

Most recent content

Methods Online
A generalized conformational energy function of DNA derived from molecular dynamics simulations
Satoshi Yamasaki, Tohru Terada, Kentaro Shimizu, Hidetoshi Kono, and Akinori Sarai
Nucleic Acids Res. 2009; 37: e135. [Abstract] [Full text] [Print PDF]  

Methods Online
A high throughput experimental approach to identify miRNA targets in human cells
Lu Ping Tan, Erwin Seinen, Gerben Duns, Debora de Jong, Ody C. M. Sibon, Sibrand Poppema, Bart-Jan Kroesen, Klaas Kok, and Anke van den Berg
Nucleic Acids Res. 2009; 37: e137. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Computational Biology
FIGfams: yet another set of protein families
Folker Meyer, Ross Overbeek, and Alex Rodriguez
Nucleic Acids Res. 2009; 37: 6643-6654. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Genomics
Selection for minimization of translational frameshifting errors as a factor in the evolution of codon usage
Yang Huang, Eugene V. Koonin, David J. Lipman, and Teresa M. Przytycka
Nucleic Acids Res. 2009; 37: 6799-6810. [Abstract] [Full text] [Print PDF] [ Supplementary Data ] [ Supplementary Data ]  

Past content

Methods Online
VENN, a tool for titrating sequence conservation onto protein structures
Jay Vyas, Michael R. Gryk, and Martin R. Schiller
Nucleic Acids Res. 2009; 37: e124. [Abstract] [Full text] [Print PDF]  

Methods Online
SubpathwayMiner: a software package for flexible identification of pathways
Chunquan Li, Xia Li, Yingbo Miao, Qianghu Wang, Wei Jiang, Chun Xu, Jing Li, Junwei Han, Fan Zhang, Binsheng Gong, and Liangde Xu
Nucleic Acids Res. 2009; 37: e131. [Abstract] [Full text] [Print PDF]  

Computational Biology
Detecting species-site dependencies in large multiple sequence alignments
Roland Schwarz, Philipp N. Seibel, Sven Rahmann, Christoph Schoen, Mirja Huenerberg, Clemens Müller-Reible, Thomas Dandekar, Rachel Karchin, Jörg Schultz, and Tobias Müller
Nucleic Acids Res. 2009; 37: 5959-5968. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Computational Biology
Combinatorial network of primary and secondary microRNA-driven regulatory mechanisms
Kang Tu, Hui Yu, You-Jia Hua, Yuan-Yuan Li, Lei Liu, Lu Xie, and Yi-Xue Li
Nucleic Acids Res. 2009; 37: 5969-5980. [Abstract] [Full text] [Print PDF] [ Supplementary Data ] [ Supplementary Data ]  

Structural Biology
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad
Kah Wai Lim, Patrizia Alberti, Aurore Guédin, Laurent Lacroix, Jean-François Riou, Nicola J. Royle, Jean-Louis Mergny, and Anh Tuân Phan
Nucleic Acids Res. 2009; 37: 6239-6248. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Computational Biology
Multiplex primer prediction software for divergent targets
Shea N. Gardner, Amy L. Hiddessen, Peter L. Williams, Christine Hara, Mark C. Wagner, and Bill W. Colston, Jr
Nucleic Acids Res. 2009; 37: 6291-6304. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

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