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Genomics


This category presents new strategies for the genomic scale analyses. Examples include, but are not limited to, positional or whole genome cloning (e.g. using HAC, BAC, YAC, or P1 systems, see also CLONING), mapping, large scale sequencing, synteny characterization and the global evaluation of genes and their expression patterns (see also MONITORING GENE EXPRESSION). Strategies involve traditional molecular biology methods as well as new technologies such as arrays.


Citations 101-110 of 258 total displayed.

Past content

Methods Online
Reversible gene knockdown in mice using a tight, inducible shRNA expression system
Jost Seibler, Andre Kleinridders, Birgit Küter-Luks, Sandra Niehaves, Jens C. Brüning, and Frieder Schwenk
Nucleic Acids Res. 2007; 35: e54. [Abstract] [Full text] [Print PDF]  

Computational Biology
Hierarchical classification of functionally equivalent genes in prokaryotes
Hongwei Wu, Fenglou Mao, Victor Olman, and Ying Xu
Nucleic Acids Res. 2007; 35: 2125-2140. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes
Rory M. Watt, Jing Wang, Meikid Leong, Hsiang-fu Kung, Kathryn S.E. Cheah, Depei Liu, Antoine Danchin, and Jian-Dong Huang
Nucleic Acids Res. 2007; 35: e37. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation
Tomasz K. Wojdacz and Alexander Dobrovic
Nucleic Acids Res. 2007; 35: e41. [Abstract] [Full text] [Print PDF]  

Methods Online
SNP discovery by mismatch-targeting of Mu transposition
Luisa Orsini, Maria Pajunen, Ilkka Hanski, and Harri Savilahti
Nucleic Acids Res. 2007; 35: e44. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans
Ismail Hassan Ismail, Tabasum Imran Wadhra, and Ola Hammarsten
Nucleic Acids Res. 2007; 35: e36. [Abstract] [Full text] [Print PDF] [ Supplementary Material ] [ Supplementary Material ]  

Methods Online
Dry-reagent disposable dipstick test for visual screening of seven leukemia-related chromosomal translocations
Despina P. Kalogianni, Vasiliki Bravou, Theodore K. Christopoulos, Penelope C. Ioannou, and Nicholas C. Zoumbos
Nucleic Acids Res. 2007; 35: e23. [Abstract] [Full text] [Print PDF]  

Methods Online
Electrospray ionisation-cleavable tandem nucleic acid mass tag–peptide nucleic acid conjugates: synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MS
Andrew Thompson, Mark Prescott, Noorhan Chelebi, John Smith, Tom Brown, and Günter Schmidt
Nucleic Acids Res. 2007; 35: e28. [Abstract] [Full text] [Print PDF]  

Methods Online
High resolution array-CGH analysis of single cells
Heike Fiegler, Jochen B. Geigl, Sabine Langer, Diane Rigler, Keith Porter, Kristian Unger, Nigel P. Carter, and Michael R. Speicher
Nucleic Acids Res. 2007; 35: e15. [Abstract] [Full text] [Print PDF]  

Methods Online
Rapid DNA mapping by fluorescent single molecule detection
Ming Xiao, Angie Phong, Connie Ha, Ting-Fung Chan, Dongmei Cai, Lucinda Leung, Eunice Wan, Amy L. Kistler, Joseph L. DeRisi, Paul R. Selvin, and Pui-Yan Kwok
Nucleic Acids Res. 2007; 35: e16. [Abstract] [Full text] [Print PDF]  

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