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Genomics


This category presents new strategies for the genomic scale analyses. Examples include, but are not limited to, positional or whole genome cloning (e.g. using HAC, BAC, YAC, or P1 systems, see also CLONING), mapping, large scale sequencing, synteny characterization and the global evaluation of genes and their expression patterns (see also MONITORING GENE EXPRESSION). Strategies involve traditional molecular biology methods as well as new technologies such as arrays.


Citations 111-120 of 258 total displayed.

Past content

Methods Online
Rapid conditional knock-down–knock-in system for mammalian cells
Michael Hölzel, Michaela Rohrmoser, Mathias Orban, Cornelia Hömig, Thomas Harasim, Anastassia Malamoussi, Anita Gruber-Eber, Vigo Heissmeyer, Georg Bornkamm, and Dirk Eick
Nucleic Acids Res. 2007; 35: e17. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats
John A. L. Armour, Raquel Palla, Patrick L. J. M. Zeeuwen, Martin den Heijer, Joost Schalkwijk, and Edward J. Hollox
Nucleic Acids Res. 2007; 35: e19. [Abstract] [Full text] [Print PDF]  

Methods Online
A semi-automated high-throughput approach to the generation of transposon insertion mutants in the nematode Caenorhabditis elegans
Yohann Duverger, Jérôme Belougne, Sarah Scaglione, Dominique Brandli, Christophe Beclin, and Jonathan J. Ewbank
Nucleic Acids Res. 2007; 35: e11. [Abstract] [Full text] [Print PDF]  

Genomics
Recharacterization of ancient DNA miscoding lesions: insights in the era of sequencing-by-synthesis
M. Thomas P. Gilbert, Jonas Binladen, Webb Miller, Carsten Wiuf, Eske Willerslev, Hendrik Poinar, John E. Carlson, James H. Leebens-Mack, and Stephan C. Schuster
Nucleic Acids Res. 2007; 35: 1-10. [Abstract] [Full text] [Print PDF] [ supplementary data ]  

Methods Online
CoMoDis: composite motif discovery in mammalian genomes
Ian J. Donaldson and Berthold Göttgens
Nucleic Acids Res. 2007; 35: e1. [Abstract] [Full text] [Print PDF]  

Methods Online
An improved method to identify BAC clones using pooled overgos
Kavitha Madishetty, Pascal Condamine, Jan T. Svensson, Edmundo Rodriguez, and Timothy J. Close
Nucleic Acids Res. 2007; 35: e5. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Gene loss rate: a probabilistic measure for the conservation of eukaryotic genes
Elhanan Borenstein, Tomer Shlomi, Eytan Ruppin, and Roded Sharan
Nucleic Acids Res. 2007; 35: e7. [Abstract] [Full text] [Print PDF]  

Computational Biology
Operon prediction using both genome-specific and general genomic information
Phuongan Dam, Victor Olman, Kyle Harris, Zhengchang Su, and Ying Xu
Nucleic Acids Res. 2007; 35: 288-298. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Gene expression profiling of single cells on large-scale oligonucleotide arrays
Claudia H. Hartmann and Christoph A. Klein
Nucleic Acids Res. 2006; 34: e143. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells
Marieke Aarts, Marleen Dekker, Sandra de Vries, Anja van der Wal, and Hein te Riele
Nucleic Acids Res. 2006; 34: e147. [Abstract] [Full text] [Print PDF]  

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