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Nucleic acid modification


This category presents chemical and biophysical methods for identifying specific modifications as well as biological approaches for assaying functional modifications of DNA and RNA and their consequences in vivo.


Citations 1-10 of 81 total displayed.

Most recent content

Nucleic Acid Enzymes
Real-time kinetics of restriction–modification gene expression after entry into a new host cell
Iwona Mruk and Robert M. Blumenthal
Nucleic Acids Res. 2008; 36: 2581-2593. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Past content

Methods Online
Bisulfite sequencing Data Presentation and Compilation (BDPC) web server—a useful tool for DNA methylation analysis
Christian Rohde, Yingying Zhang, Tomasz P. Jurkowski, Heinrich Stamerjohanns, Richard Reinhardt, and Albert Jeltsch
Nucleic Acids Res. 2008; 36: e34. [Abstract] [Full text] [Print PDF]  

Methods Online
A ligation assay for multiplex analysis of CpG methylation using bisulfite-treated DNA
Christina Dahl and Per Guldberg
Nucleic Acids Res. 2007; 35: e144. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Chemistry
Termination of DNA synthesis by N6-alkylated, not 3'-O-alkylated, photocleavable 2'-deoxyadenosine triphosphates
Weidong Wu, Brian P. Stupi, Vladislav A. Litosh, Dena Mansouri, Demetra Farley, Sidney Morris, Sherry Metzker, and Michael L. Metzker
Nucleic Acids Res. 2007; 35: 6339-6349. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
A rapid high-throughput method for the detection and quantification of RNA editing based on high-resolution melting of amplicons
Anne-Laure Chateigner-Boutin and Ian Small
Nucleic Acids Res. 2007; 35: e114. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements
Marcel W. Coolen, Aaron L. Statham, Margaret Gardiner-Garden, and Susan J. Clark
Nucleic Acids Res. 2007; 35: e119. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Selection of restriction endonucleases using artificial cells
Yu Zheng and Richard J. Roberts
Nucleic Acids Res. 2007; 35: e83. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
A facile method for attaching nitroxide spin labels at the 5' terminus of nucleic acids
Gian Paola G. Grant and Peter Z. Qin
Nucleic Acids Res. 2007; 35: e77. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Sequence analysis and editing for bisulphite genomic sequencing projects
Ian M. Carr, Elizabeth M. A. Valleley, Sarah F. Cordery, Alexander F. Markham, and David T. Bonthron
Nucleic Acids Res. 2007; 35: e79. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
A new method for accurate assessment of DNA quality after bisulfite treatment
Mathias Ehrich, Scott Zoll, Sudipto Sur, and Dirk van den Boom
Nucleic Acids Res. 2007; 35: e29. [Abstract] [Full text] [Print PDF] [ Supplementary Material ] [ Supplementary Material ]  

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