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Nucleic acid modification


This category presents chemical and biophysical methods for identifying specific modifications as well as biological approaches for assaying functional modifications of DNA and RNA and their consequences in vivo.


Citations 1-10 of 94 total displayed.

Most recent content

Gene Regulation, Chromatin and Epigenetics
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers
Mayumi Oda, Jacob L. Glass, Reid F. Thompson, Yongkai Mo, Emmanuel N. Olivier, Maria E. Figueroa, Rebecca R. Selzer, Todd A. Richmond, Xinmin Zhang, Luke Dannenberg, Roland D. Green, Ari Melnick, Eli Hatchwell, Eric E. Bouhassira, Amit Verma, Masako Suzuki, and John M. Greally
Nucleic Acids Res. 2009; 37: 3829-3839. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Past content

Nucleic Acid Enzymes
Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands
Kelly L. Sanders, Lucy E. Catto, Stuart R. W. Bellamy, and Stephen E. Halford
Nucleic Acids Res. 2009; 37: 2105-2115. [Abstract] [Full text] [Print PDF]  

Methods Online
Scintillation proximity assay for measurement of RNA methylation
Matthew R. Baker, Tamara Zarubica, H. Tonie Wright, and Jason P. Rife
Nucleic Acids Res. 2009; 37: e32. [Abstract] [Full text] [Print PDF]  

Methods Online
A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding
Carina Frauer and Heinrich Leonhardt
Nucleic Acids Res. 2009; 37: e22. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
DNA methylation determination by liquid chromatography–tandem mass spectrometry using novel biosynthetic [U-15N]deoxycytidine and [U-15N]methyldeoxycytidine internal standards
Eoin P. Quinlivan and Jesse F. Gregory, III
Nucleic Acids Res. 2008; 36: e119. [Abstract] [Full text] [Print PDF]  

Methods Online
Detection of Adriamycin–DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations
Kate E. Coldwell, Suzanne M. Cutts, Ted J. Ognibene, Paul T. Henderson, and Don R. Phillips
Nucleic Acids Res. 2008; 36: e100. [Abstract] [Full text] [Print PDF]  

Methods Online
End-joining long nucleic acid polymers
M. van den Hout, S. Hage, C. Dekker, and N. H. Dekker
Nucleic Acids Res. 2008; 36: e104. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx)
Amy J. Baldwin, Kathy Busse, Alan M. Simm, and D. Dafydd Jones
Nucleic Acids Res. 2008; 36: e77. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Real-time detection of Fe·EDTA/H2O2-induced DNA cleavage by linear dichroism
Wei Wang, Gil Jun Lee, Kyeung Joo Jang, Tae Sub Cho, and Seog K. Kim
Nucleic Acids Res. 2008; 36: e85. [Abstract] [Full text] [Print PDF]  

Methods Online
Multiple segmental and selective isotope labeling of large RNA for NMR structural studies
Frank H. T. Nelissen, Adriaan J. van Gammeren, Marco Tessari, Frederic C. Girard, Hans A. Heus, and Sybren S. Wijmenga
Nucleic Acids Res. 2008; 36: e89. [Abstract] [Full text] [Print PDF]  

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