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Nucleic acid modification


This category presents chemical and biophysical methods for identifying specific modifications as well as biological approaches for assaying functional modifications of DNA and RNA and their consequences in vivo.

Citations 41-50 of 94 total displayed.

Past content

Methods Online
Real-time investigation of nucleic acids phosphorylation process using molecular beacons
Zhiwen Tang, Kemin Wang, Weihong Tan, Changbei Ma, Jun Li, Lingfeng Liu, Qiuping Guo, and Xiangxian Meng
Nucleic Acids Res. 2005; 33: e97. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions
Zachary A. Kaminsky, Abbas Assadzadeh, James Flanagan, and Arturas Petronis
Nucleic Acids Res. 2005; 33: e95. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
MSRE-PCR for analysis of gene-specific DNA methylation
Anatoliy A. Melnikov, Ronald B. Gartenhaus, Anait S. Levenson, Natalia A. Motchoulskaia, and Victor V. Levenson (Chernokhvostov)
Nucleic Acids Res. 2005; 33: e93. [Abstract] [Full text] [Print PDF]  

Methods Online
Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines
Cora Mund, Verena Beier, Peter Bewerunge, Michael Dahms, Frank Lyko, and Jörg D. Hoheisel
Nucleic Acids Res. 2005; 33: e73. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Articles
Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors
Lindsay R. Comstock and Scott R. Rajski
Nucleic Acids Res. 2005; 33: 1644-1652. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Articles
Site-specific labeling of the ribosome for single-molecule spectroscopy
Magdalena Dorywalska, Scott C. Blanchard, Ruben L. Gonzalez, Harold D. Kim, Steven Chu, and Joseph D. Puglisi
Nucleic Acids Res. 2005; 33: 182-189. [Abstract] [Full text] [Print PDF]  

Methods Online
MethylQuant: a sensitive method for quantifying methylation of specific cytosines within the genome
Hélène Thomassin, Clémence Kress, and Thierry Grange
Nucleic Acids Res. 2004; 32: e168. [Abstract] [Full text] [Print PDF]  

Methods Online
Rapid analysis of CpG methylation patterns using RNase T1 cleavage and MALDI-TOF
Philipp Schatz, Dimo Dietrich, and Matthias Schuster
Nucleic Acids Res. 2004; 32: e167. [Abstract] [Full text] [Print PDF]  

Methods Online
Site-selective and hydrolytic two-strand scission of double-stranded DNA using Ce(IV)/EDTA and pseudo-complementary PNA
Yoji Yamamoto, Akihiko Uehara, Takafumi Tomita, and Makoto Komiyama
Nucleic Acids Res. 2004; 32: e153. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Articles
Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules
J. B. Opalinska, A. Kalota, Lida K. Gifford, Ponzy Lu, Kuang-Yu Jen, P. I. Pradeepkumar, J. Barman, T. K. Kim, C. R. Swider, J. Chattopadhyaya, and A. M. Gewirtz
Nucleic Acids Res. 2004; 32: 5791-5799. [Abstract] [Full text] [Print PDF]  

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