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Nucleic acid modification


This category presents chemical and biophysical methods for identifying specific modifications as well as biological approaches for assaying functional modifications of DNA and RNA and their consequences in vivo.


Citations 81-90 of 94 total displayed.

Past content

Articles
Covalent attachment of oligodeoxyribonucleotides to amine-modified Si (001) surfaces
Todd Strother, Robert J. Hamers, and Lloyd M. Smith
Nucleic Acids Res. 2000; 28: 3535-3541. [Abstract] [Full text] [Print PDF]  

Articles
The precursor strategy: terminus methoxyoxalamido modifiers for single and multiple functionalization of oligodeoxyribonucleotides
Nikolai N. Polushin
Nucleic Acids Res. 2000; 28: 3125-3133. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages
Daniel C. Capaldi, Douglas L. Cole, and Vasulinga T. Ravikumar
Nucleic Acids Res. 2000; 28: e40. [Abstract] [Full text] [Print PDF]  

Articles
Analysis of chemical modification of RNA from formalin-fixed samples and optimization of molecular biology applications for such samples
N Masuda, T Ohnishi, S Kawamoto, M Monden, and K Okubo
Nucleic Acids Res. 1999; 27: 4436-4443. [Abstract] [Full text] [Print PDF]  

Articles
Design of modified oligodeoxyribonucleotide probes to detect telomere repeat sequences in FISH assays
JG Hacia, EA Novotny, RA Mayer, SA Woski, MA Ashlock, and FS Collins
Nucleic Acids Res. 1999; 27: 4034-4039. [Abstract] [Full text] [Print PDF]  

Articles
An in vitro screening technique for DNA polymerases that can incorporate modified nucleotides. Pseudo-thymidine as a substrate for thermostable polymerases
S Lutz, P Burgstaller, and SA Benner
Nucleic Acids Res. 1999; 27: 2792-2798. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Articles
Reactivity of potassium permanganate and tetraethylammonium chloride with mismatched bases and a simple mutation detection protocol
A Lambrinakos, KE Humphrey, JJ Babon, TP Ellis, and RG Cotton
Nucleic Acids Res. 1999; 27: 1866-1874. [Abstract] [Full text] [Print PDF]  

Articles
Efficient synthesis of nucleic acids heavily modified with non- canonical ribose 2'-groups using a mutantT7 RNA polymerase (RNAP)
R Padilla and R Sousa
Nucleic Acids Res. 1999; 27: 1561-1563. [Abstract] [Full text] [Print PDF]  

Articles
Novel non-isotopic detection of MutY enzyme-recognized mismatches in DNA via ultrasensitive detection of aldehydes
G Maulik, S Botchway, S Chakrabarti, S Tetradis, B Price, and GM Makrigiorgos
Nucleic Acids Res. 1999; 27: 1316-1322. [Abstract] [Full text] [Print PDF]  

Articles
Visualizing tertiary folding of RNA and RNA-protein interactions by a tethered iron chelate: analysis ofHIV-1 Tat-TAR complex
I Huq, N Tamilarasu, and TM Rana
Nucleic Acids Res. 1999; 27: 1084-1093. [Abstract] [Full text] [Print PDF]  

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