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Nucleic acid structure


This category presents methods to analyze nucleic acid structure either indirectly (e.g. by chemical probing, using electrophoresis) or directly (e.g. using fluorescence, NMR or crystallography). Specific methods to prepare nucleic acid samples for structural analyses are also described.


Citations 1-10 of 44 total displayed.

Most recent content

Methods Online
Measuring the dynamic surface accessibility of RNA with the small paramagnetic molecule TEMPOL
Vincenzo Venditti, Neri Niccolai, and Samuel E. Butcher
Nucleic Acids Res. 2008; 36: e20. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Cell-free cloning of highly expanded CTG repeats by amplification of dimerized expanded repeats
Robert J. Osborne and Charles A. Thornton
Nucleic Acids Res. 2008; 36: e24. [Abstract] [Full text] [Print PDF]  

Methods Online
A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Gerardo Turcatti, Anthony Romieu, Milan Fedurco, and Ana-Paula Tairi
Nucleic Acids Res. 2008; 36: e25. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Past content

Methods Online
Direct observation of the reversible unwinding of a single DNA molecule caused by the intercalation of ethidium bromide
Masahito Hayashi and Yoshie Harada
Nucleic Acids Res. 2007; 35: e125. [Abstract] [Full text] [Print PDF]  

Methods Online
An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
Yuan Yao, Quan Wang, Yu-hua Hao, and Zheng Tan
Nucleic Acids Res. 2007; 35: e68. [Abstract] [Full text] [Print PDF]  

RNA
Use of a novel Förster resonance energy transfer method to identify locations of site-bound metal ions in the U2–U6 snRNA complex
Faqing Yuan, Laura Griffin, LauraJane Phelps, Volker Buschmann, Kenneth Weston, and Nancy L. Greenbaum
Nucleic Acids Res. 2007; 35: 2833-2845. [Abstract] [Full text] [Print PDF]  

Methods Online
A facile method for attaching nitroxide spin labels at the 5' terminus of nucleic acids
Gian Paola G. Grant and Peter Z. Qin
Nucleic Acids Res. 2007; 35: e77. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Specific residues at every third position of siRNA shape its efficient RNAi activity
Takayuki Katoh and Tsutomu Suzuki
Nucleic Acids Res. 2007; 35: e27. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli
Nobutaka Nakashima, Tomohiro Tamura, and Liam Good
Nucleic Acids Res. 2006; 34: e138. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Using RNA secondary structures to guide sequence motif finding towards single-stranded regions
Michael Hiller, Rainer Pudimat, Anke Busch, and Rolf Backofen
Nucleic Acids Res. 2006; 34: e117. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

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