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Nucleic acid structure


This category presents methods to analyze nucleic acid structure either indirectly (e.g. by chemical probing, using electrophoresis) or directly (e.g. using fluorescence, NMR or crystallography). Specific methods to prepare nucleic acid samples for structural analyses are also described.


Citations 11-20 of 59 total displayed.

Past content

Methods Online
Sensing peptide–oligonucleotide interactions by a two-color fluorescence label: application to the HIV-1 nucleocapsid protein
Volodymyr V. Shvadchak, Andrey S. Klymchenko, Hugues de Rocquigny, and Yves Mély
Nucleic Acids Res. 2009; 37: e25. [Abstract] [Full text] [Print PDF]  

Structural Biology
Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity
Ji Wook Shim, Qiulin Tan, and Li-Qun Gu
Nucleic Acids Res. 2009; 37: 972-982. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Chemistry and Synthetic Biology
Assembling of G-strands into novel tetra-molecular parallel G4-DNA nanostructures using avidin–biotin recognition
Natalia Borovok, Natalie Iram, Dragoslav Zikich, Jamal Ghabboun, Gideon I. Livshits, Danny Porath, and Alexander B. Kotlyar
Nucleic Acids Res. 2008; 36: 5050-5060. [Abstract] [Full text] [Print PDF]  

Structural Biology
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
Joseph D. Bauman, Kalyan Das, William C. Ho, Mukta Baweja, Daniel M. Himmel, Arthur D. Clark, Jr, Deena A. Oren, Paul L. Boyer, Stephen H. Hughes, Aaron J. Shatkin, and Eddy Arnold
Nucleic Acids Res. 2008; 36: 5083-5092. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Chemical mapping of cytosines enzymatically flipped out of the DNA helix
Dalia Daujotyte, Zita Liutkeviciute, Gintautas Tamulaitis, and Saulius Klimasauskas
Nucleic Acids Res. 2008; 36: e57. [Abstract] [Full text] [Print PDF]  

Methods Online
Measuring the dynamic surface accessibility of RNA with the small paramagnetic molecule TEMPOL
Vincenzo Venditti, Neri Niccolai, and Samuel E. Butcher
Nucleic Acids Res. 2008; 36: e20. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Cell-free cloning of highly expanded CTG repeats by amplification of dimerized expanded repeats
Robert J. Osborne and Charles A. Thornton
Nucleic Acids Res. 2008; 36: e24. [Abstract] [Full text] [Print PDF]  

Methods Online
A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Gerardo Turcatti, Anthony Romieu, Milan Fedurco, and Ana-Paula Tairi
Nucleic Acids Res. 2008; 36: e25. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Direct observation of the reversible unwinding of a single DNA molecule caused by the intercalation of ethidium bromide
Masahito Hayashi and Yoshie Harada
Nucleic Acids Res. 2007; 35: e125. [Abstract] [Full text] [Print PDF]  

Methods Online
An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
Yuan Yao, Quan Wang, Yu-hua Hao, and Zheng Tan
Nucleic Acids Res. 2007; 35: e68. [Abstract] [Full text] [Print PDF]  

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