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Nucleic acid structure


This category presents methods to analyze nucleic acid structure either indirectly (e.g. by chemical probing, using electrophoresis) or directly (e.g. using fluorescence, NMR or crystallography). Specific methods to prepare nucleic acid samples for structural analyses are also described.


Citations 41-50 of 59 total displayed.

Past content

Articles
Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract
Chandravanu Dash, Jason W. Rausch, and Stuart F. J. Le Grice
Nucleic Acids Res. 2004; 32: 1539-1547. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Two-dimensional conformation-dependent electrophoresis (2D-CDE) to separate DNA fragments containing unmatched bulge from complex DNA samples
Gudmundur H. Gunnarsson, Hans G. Thormar, Bjarki Gudmundsson, Lina Akesson, and Jon J. Jonsson
Nucleic Acids Res. 2004; 32: e23. [Abstract] [Full text] [Print PDF]  

Articles
Probing alternative foldings of the HIV-1 leader RNA by antisense oligonucleotide scanning arrays
Marcel Ooms, Koen Verhoef, Edwin Southern, Hendrik Huthoff, and Ben Berkhout
Nucleic Acids Res. 2004; 32: 819-827. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Polylysine-coated mica can be used to observe systematic changes in the supercoiled DNA conformation by scanning force microscopy in solution
Malte Bussiek, Norbert Mücke, and Jörg Langowski
Nucleic Acids Res. 2003; 31: e137. [Abstract] [Full text] [Print PDF]  

Articles
Automated identification of RNA conformational motifs: theory and application to the HM LSU 23S rRNA
Eli Hershkovitz, Emmanuel Tannenbaum, Shelley B. Howerton, Ajay Sheth, Allen Tannenbaum, and Loren Dean Williams
Nucleic Acids Res. 2003; 31: 6249-6257. [Abstract] [Full text] [Print PDF]  

Articles
Biopolymer Chain Elasticity: a novel concept and a least deformation energy principle predicts backbone and overall folding of DNA TTT hairpins in agreement with NMR distances
Christophe Pakleza and Jean A. H. Cognet
Nucleic Acids Res. 2003; 31: 1075-1085. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Synthesis and evaluation of phosphorescent oligonucleotide probes for hybridisation assays
Paul J. O’Sullivan, Martina Burke, Aleksi E. Soini, and Dmitri B. Papkovsky
Nucleic Acids Res. 2002; 30: e114. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Multivariate curve resolution: a powerful tool for the analysis of conformational transitions in nucleic acids
Joaquim Jaumot, Núria Escaja, Raimundo Gargallo, Carlos González, Enrique Pedroso, and Romà Tauler
Nucleic Acids Res. 2002; 30: e92. [Abstract] [Full text] [Print PDF]  

Articles
A protonated base pair participating in rRNA tertiary structural interactions
Andriy V. Kubarenko, Petr V. Sergiev, Alexey A. Bogdanov, Richard Brimacombe, and Olga A. Dontsova
Nucleic Acids Res. 2001; 29: 5067-5070. [Abstract] [Full text] [Print PDF]  

Articles
-CH2- lengthening of the internucleotide linkage in the ApA dimer can improve its conformational compatibility with its natural polynucleotide counterpart
J. Hanus, I. Barvík, K. Ruszová-Chmelová, J. Stepánek, P.-Y. Turpin, J. Bok, I. Rosenberg, and M. Petrová-Endová
Nucleic Acids Res. 2001; 29: 5182-5194. [Abstract] [Full text] [Print PDF]  

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