Targeted inhibition of gene function

Citations 21-30 of 91 total displayed.

Past content

Molecular Biology
Development of an isoform-specific gene suppression system: the study of the human Pax-5B transcriptional element

Gilles A. Robichaud, Jean-Pierre Perreault, and Rodney J. Ouellette
Nucleic Acids Res. 2008; 36: 4609-4620. [Abstract] [Full text] [Print PDF]  

Computational Biology
Hit selection with false discovery rate control in genome-scale RNAi screens

Xiaohua Douglas Zhang, Pei Fen Kuan, Marc Ferrer, Xiaohua Shu, Yingxue C. Liu, Adam T. Gates, Priya Kunapuli, Erica M. Stec, Min Xu, Shane D. Marine, Daniel J. Holder, Berta Strulovici, Joseph F. Heyse, and Amy S. Espeseth
Nucleic Acids Res. 2008; 36: 4667-4679. [Abstract] [Full text] [Print PDF]  

Methods Online
Analysis of siRNA specificity on targets with double-nucleotide mismatches

Cecilia Dahlgren, Hong-Yan Zhang, Quan Du, Maria Grahn, Gunnar Norstedt, Claes Wahlestedt, and Zicai Liang
Nucleic Acids Res. 2008; 36: e53. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Chemistry
Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences

Takumi Ishizuka, Junya Yoshida, Yoji Yamamoto, Jun Sumaoka, Tullia Tedeschi, Roberto Corradini, Stefano Sforza, and Makoto Komiyama
Nucleic Acids Res. 2008; 36: 1464-1471. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon

Takuma Gondai, Kazuya Yamaguchi, Naoko Miyano-Kurosaki, Yuichirou Habu, and Hiroshi Takaku
Nucleic Acids Res. 2008; 36: e18. [Abstract] [Full text] [Print PDF]  

Methods Online
siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma

Henri de Martimprey, Jean-Remi Bertrand, Alfredo Fusco, Massimo Santoro, Patrick Couvreur, Christine Vauthier, and Claude Malvy
Nucleic Acids Res. 2008; 36: e2. [Abstract] [Full text] [Print PDF]  

Methods Online
Comprehensive viral oligonucleotide probe design using conserved protein regions

Omar J. Jabado, Yang Liu, Sean Conlan, P. Lan Quan, Hédi Hegyi, Yves Lussier, Thomas Briese, Gustavo Palacios, and W. I. Lipkin
Nucleic Acids Res. 2008; 36: e3. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Lentivirus-mediated antagomir expression for specific inhibition of miRNA function

Michaela Scherr, Letizia Venturini, Karin Battmer, Michael Schaller-Schoenitz, Daniel Schaefer, Iris Dallmann, Arnold Ganser, and Matthias Eder
Nucleic Acids Res. 2007; 35: e149. [Abstract] [Full text] [Print PDF]  

RNA
Improved silencing properties using small internally segmented interfering RNAs

Jesper B. Bramsen, Maria B. Laursen, Christian K. Damgaard, Suzy W. Lena, B. Ravindra Babu, Jesper Wengel, and Jørgen Kjems
Nucleic Acids Res. 2007; 35: 5886-5897. [Abstract] [Full text] [Print PDF]  

Methods Online
Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities

Masatoshi Ichihara, Yoshiki Murakumo, Akio Masuda, Toru Matsuura, Naoya Asai, Mayumi Jijiwa, Maki Ishida, Jun Shinmi, Hiroshi Yatsuya, Shanlou Qiao, Masahide Takahashi, and Kinji Ohno
Nucleic Acids Res. 2007; 35: e123. [Abstract] [Full text] [Print PDF] [ Supplementary Data ] [ Supplementary Data ]  

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