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Targeted inhibition of gene function


This category covers new developments using RNA and oligonucleotide strategies for specific inhibition of gene function. Examples include antisense, ribozymes, triplex and RNAi.


Citations 31-40 of 91 total displayed.

Past content

Methods Online
Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference
Christiane Hitz, Wolfgang Wurst, and Ralf Kühn
Nucleic Acids Res. 2007; 35: e90. [Abstract] [Full text] [Print PDF]  

Methods Online
A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain
Zahra Hassani, Jean-Christophe François, Gladys Alfama, Ghislaine Morvan Dubois, Mathilde Paris, Carine Giovannangeli, and Barbara A. Demeneix
Nucleic Acids Res. 2007; 35: e65. [Abstract] [Full text] [Print PDF]  

Methods Online
Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines
Jørn R. Henriksen, Cecilie Løkke, Martin Hammerø, Dirk Geerts, Rogier Versteeg, Trond Flægstad, and Christer Einvik
Nucleic Acids Res. 2007; 35: e67. [Abstract] [Full text] [Print PDF]  

Methods Online
Multiplexing siRNAs to compress RNAi-based screen size in human cells
Scott E. Martin, Tamara L. Jones, Cheryl L. Thomas, Philip L. Lorenzi, Dac A. Nguyen, Timothy Runfola, Michele Gunsior, John N. Weinstein, Paul K. Goldsmith, Eric Lader, Konrad Huppi, and Natasha J. Caplen
Nucleic Acids Res. 2007; 35: e57. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Comparison of approaches for rational siRNA design leading to a new efficient and transparent method
Olga Matveeva, Yury Nechipurenko, Leo Rossi, Barry Moore, Pål Sætrom, Aleksey Y. Ogurtsov, John F. Atkins, and Svetlana A. Shabalina
Nucleic Acids Res. 2007; 35: e63. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
A non-covalent peptide-based carrier for in vivo delivery of DNA mimics
May C. Morris, Edwige Gros, Gudrun Aldrian-Herrada, Michael Choob, John Archdeacon, Frederic Heitz, and Gilles Divita
Nucleic Acids Res. 2007; 35: e49. [Abstract] [Full text] [Print PDF]  

Methods Online
Reversible gene knockdown in mice using a tight, inducible shRNA expression system
Jost Seibler, Andre Kleinridders, Birgit Küter-Luks, Sandra Niehaves, Jens C. Brüning, and Frieder Schwenk
Nucleic Acids Res. 2007; 35: e54. [Abstract] [Full text] [Print PDF]  

Methods Online
An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells
Hoi Tang Ma, Kin Fan On, Yiu Huen Tsang, and Randy Y.C. Poon
Nucleic Acids Res. 2007; 35: e22. [Abstract] [Full text] [Print PDF]  

Methods Online
Specific residues at every third position of siRNA shape its efficient RNAi activity
Takayuki Katoh and Tsutomu Suzuki
Nucleic Acids Res. 2007; 35: e27. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Rapid conditional knock-down–knock-in system for mammalian cells
Michael Hölzel, Michaela Rohrmoser, Mathias Orban, Cornelia Hömig, Thomas Harasim, Anastassia Malamoussi, Anita Gruber-Eber, Vigo Heissmeyer, Georg Bornkamm, and Dirk Eick
Nucleic Acids Res. 2007; 35: e17. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

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