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Targeted inhibition of gene function


This category covers new developments using RNA and oligonucleotide strategies for specific inhibition of gene function. Examples include antisense, ribozymes, triplex and RNAi.


Citations 41-50 of 91 total displayed.

Past content

RNA
Translational control and target recognition by Escherichia coli small RNAs in vivo
Johannes H. Urban and Jörg Vogel
Nucleic Acids Res. 2007; 35: 1018-1037. [Abstract] [Full text] [Print PDF]  

Methods Online
Development of a species-specific RNA polymerase I-based shRNA expression vector
M. S. Brenz Verca, Peter Weber, Christine Mayer, Cornelia Graf, Damián Refojo, Ralf Kühn, Ingrid Grummt, and Beat Lutz
Nucleic Acids Res. 2007; 35: e10. [Abstract] [Full text] [Print PDF]  

Molecular Biology
Different modes and potencies of translational repression by sequence-specific RNA–protein interaction at the 5'-UTR
Minghua Nie and Han Htun
Nucleic Acids Res. 2006; 34: 5528-5540. [Abstract] [Full text] [Print PDF]  

Molecular Biology
Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules
Alessandra Mescalchin, Winfried Wünsche, Sandra D. Laufer, Dina Grohmann, Tobias Restle, and Georg Sczakiel
Nucleic Acids Res. 2006; 34: 5631-5637. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Computational Biology
Rational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation
Yu Shao, Yan Wu, Chi Yu Chan, Kathleen McDonough, and Ye Ding
Nucleic Acids Res. 2006; 34: 5660-5669. [Abstract] [Full text] [Print PDF]  

Methods Online
Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli
Nobutaka Nakashima, Tomohiro Tamura, and Liam Good
Nucleic Acids Res. 2006; 34: e138. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

RNA
Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli
Omid R. Faridani, Abbas Nikravesh, Deo Prakash Pandey, Kenn Gerdes, and Liam Good
Nucleic Acids Res. 2006; 34: 5915-5922. [Abstract] [Full text] [Print PDF]  

Methods Online
Inducible microRNA expression by an all-in-one episomal vector system
Alexey Epanchintsev, Peter Jung, Antje Menssen, and Heiko Hermeking
Nucleic Acids Res. 2006; 34: e119. [Abstract] [Full text] [Print PDF]  

Articles
Specific and nontoxic silencing in mammalian cells with expressed long dsRNAs
Aurel Strat, Lu Gao, Tada Utsuki, Bing Cheng, Sam Nuthalapaty, J. Mike Mathis, Yoshinobu Odaka, and Tony Giordano
Nucleic Acids Res. 2006; 34: 3803-3810. [Abstract] [Full text] [Print PDF] [ Supplementary Data ]  

Methods Online
Aptamer mediated siRNA delivery
Ted C. Chu, Karen Y. Twu, Andrew D. Ellington, and Matthew Levy
Nucleic Acids Res. 2006; 34: e73. [Abstract] [Full text] [Print PDF]  

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