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Targeted inhibition of gene function


This category covers new developments using RNA and oligonucleotide strategies for specific inhibition of gene function. Examples include antisense, ribozymes, triplex and RNAi.


Citations 61-70 of 91 total displayed.

Past content

Methods Online
RNA interference by mixtures of siRNAs prepared using custom oligonucleotide arrays
Andrew V. Oleinikov, Jun Zhao, and Matthew D. Gray
Nucleic Acids Res. 2005; 33: e92. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei
Masakiyo Sakaguchi, Takamasa Nukui, Hiroyuki Sonegawa, Hitoshi Murata, Junichiro Futami, Hidenori Yamada, and Nam-ho Huh
Nucleic Acids Res. 2005; 33: e88. [Abstract] [Full text] [Print PDF]  

Methods Online
Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels
Heung-Sun Kwon, Hyun-Chul Shin, and Jin-Soo Kim
Nucleic Acids Res. 2005; 33: e74. [Abstract] [Full text] [Print PDF]  

Methods Online
Single copy shRNA configuration for ubiquitous gene knockdown in mice
Jost Seibler, Birgit Küter-Luks, Heidrun Kern, Sandra Streu, Leona Plum, Jan Mauer, Ralf Kühn, Jens C. Brüning, and Frieder Schwenk
Nucleic Acids Res. 2005; 33: e67. [Abstract] [Full text] [Print PDF]  

Methods Online
An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi
Hongxia Zhou, Xu Gang Xia, and Zuoshang Xu
Nucleic Acids Res. 2005; 33: e62. [Abstract] [Full text] [Print PDF]  

Methods Online
L1 retrotransposon-mediated stable gene silencing
Nuo Yang, Lin Zhang, and Haig H. Kazazian, Jr
Nucleic Acids Res. 2005; 33: e57. [Abstract] [Full text] [Print PDF]  

Methods Online
siRNA target site secondary structure predictions using local stable substructures
Bret S. E. Heale, Harris S. Soifer, Chauncey Bowers, and John J. Rossi
Nucleic Acids Res. 2005; 33: e30. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Dissecting RNA silencing in protoplasts uncovers novel effects of viral suppressors on the silencing pathway at the cellular level
Yijun Qi, Xuehua Zhong, Asuka Itaya, and Biao Ding
Nucleic Acids Res. 2004; 32: e179. [Abstract] [Full text] [Print PDF]  

Methods Online
RNA silencing in plants by the expression of siRNA duplexes
Shanfa Lu, Rui Shi, Cheng-Chung Tsao, Xiaoping Yi, Laigeng Li, and Vincent L. Chiang
Nucleic Acids Res. 2004; 32: e171. [Abstract] [Full text] [Print PDF]  

Methods Online
Quantitative detection of siRNA and single-stranded oligonucleotides: relationship between uptake and biological activity of siRNA
Marita Overhoff, Winfried Wünsche, and Georg Sczakiel
Nucleic Acids Res. 2004; 32: e170. [Abstract] [Full text] [Print PDF]  

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