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Targeted inhibition of gene function


This category covers new developments using RNA and oligonucleotide strategies for specific inhibition of gene function. Examples include antisense, ribozymes, triplex and RNAi.


Citations 71-80 of 91 total displayed.

Past content

Methods Online
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
Raymond M. Schiffelers, Aslam Ansari, Jun Xu, Qin Zhou, Qingquan Tang, Gert Storm, Grietje Molema, Patrick Y. Lu, Puthupparampil V. Scaria, and Martin C. Woodle
Nucleic Acids Res. 2004; 32: e149. [Abstract] [Full text] [Print PDF]  

Methods Online
Subcellular localization as a limiting factor for utilization of decoy oligonucleotides
Anca Bene, Richard C. Kurten, and Timothy C. Chambers
Nucleic Acids Res. 2004; 32: e142. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo
Deming Gou, Telugu Narasaraju, Narendranath Reddy Chintagari, Nili Jin, Pengcheng Wang, and Lin Liu
Nucleic Acids Res. 2004; 32: e134. [Abstract] [Full text] [Print PDF]  

Articles
Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine–PNA (peptide nucleic acid) conjugates
Takehiko Shiraishi and Peter E. Nielsen
Nucleic Acids Res. 2004; 32: 4893-4902. [Abstract] [Full text] [Print PDF]  

Methods Online
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
Yoshiko Minakuchi, Fumitaka Takeshita, Nobuyoshi Kosaka, Hideo Sasaki, Yusuke Yamamoto, Makiko Kouno, Kimi Honma, Shunji Nagahara, Koji Hanai, Akihiko Sano, Takashi Kato, Masaaki Terada, and Takahiro Ochiya
Nucleic Acids Res. 2004; 32: e109. [Abstract] [Full text] [Print PDF]  

Articles
siRNA-mediated gene silencing: a global genome view
Dimitri Semizarov, Paul Kroeger, and Stephen Fesik
Nucleic Acids Res. 2004; 32: 3836-3845. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

Methods Online
A universal transgene silencing method based on RNA interference
Philippe-Emmanuel Mangeot, François-Loïc Cosset, Pierre Colas, and Ivan Mikaelian
Nucleic Acids Res. 2004; 32: e102. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Control of siRNA expression using the Cre–loxP recombination system
Vivi Kasim, Makoto Miyagishi, and Kazunari Taira
Nucleic Acids Res. 2004; 32: e66. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
siRNA relieves chronic neuropathic pain
Gabriele Dorn, Sadhana Patel, Glen Wotherspoon, Maja Hemmings-Mieszczak, Jane Barclay, Francois J. C. Natt, Pierre Martin, Stuart Bevan, Alyson Fox, Pam Ganju, William Wishart, and Jonathan Hall
Nucleic Acids Res. 2004; 32: e49. [Abstract] [Full text] [Print PDF]  

Articles
Modified U1 snRNA suppresses expression of a targeted endogenous RNA by inhibiting polyadenylation of the transcript
Peng Liu, Mark Kronenberg, Xi Jiang, and David Rowe
Nucleic Acids Res. 2004; 32: 1512-1517. [Abstract] [Full text] [Print PDF]  

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