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Targeted inhibition of gene function


This category covers new developments using RNA and oligonucleotide strategies for specific inhibition of gene function. Examples include antisense, ribozymes, triplex and RNAi.


Citations 81-90 of 91 total displayed.

Past content

NAR Methods Online
A novel approach for evaluating the efficiency of siRNAs on protein levels in cultured cells
Weilin Wu, Emily Hodges, Jenny Redelius, and Christer Höög
Nucleic Acids Res. 2004; 32: e17. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Suppression of gene expression by a cell-permeable Tet repressor
Alison Mortlock, Walter Low, and Andrea Crisanti
Nucleic Acids Res. 2003; 31: e152. [Abstract] [Full text] [Print PDF]  

Articles
Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies
Akira Goto, Stéphanie Blandin, Julien Royet, Jean-Marc Reichhart, and Elena A. Levashina
Nucleic Acids Res. 2003; 31: 6619-6623. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Inducible shRNA expression for application in a prostate cancer mouse model
Frank Czauderna, Ansgar Santel, Michael Hinz, Melanie Fechtner, Birgit Durieux, Gerald Fisch, Frauke Leenders, Wolfgang Arnold, Klaus Giese, Anke Klippel, and Jörg Kaufmann
Nucleic Acids Res. 2003; 31: e127. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
An enhanced U6 promoter for synthesis of short hairpin RNA
Xu Gang Xia, Hongxia Zhou, Hongliu Ding, El Bashir Affar, Yang Shi, and Zuoshang Xu
Nucleic Acids Res. 2003; 31: e100. [Abstract] [Full text] [Print PDF]  

Articles
Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes
Alexandra Boutla, Christos Delidakis, and Martin Tabler
Nucleic Acids Res. 2003; 31: 4973-4980. [Abstract] [Full text] [Print PDF] [ Supplementary Material ]  

NAR Methods Online
Establishment of conditional vectors for hairpin siRNA knockdowns
Shiro Matsukura, Peter A. Jones, and Daiya Takai
Nucleic Acids Res. 2003; 31: e77. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Fast and accurate determination of sites along the FUT2 in vitro transcript that are accessible to antisense oligonucleotides by application of secondary structure predictions and RNase H in combination with MALDI-TOF mass spectrometry
Angelika Gabler, Stefan Krebs, Doris Seichter, and Martin Förster
Nucleic Acids Res. 2003; 31: e79. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
Stable and heritable gene silencing in the malaria vector Anopheles stephensi
Anthony E. Brown, Laurence Bugeon, Andrea Crisanti, and Flaminia Catteruccia
Nucleic Acids Res. 2003; 31: e85. [Abstract] [Full text] [Print PDF]  

NAR Methods Online
mRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotides
Hong-Yan Zhang, Jianping Mao, Daixing Zhou, Yunhe Xu, Håkan Thonberg, Zicai Liang, and Claes Wahlestedt
Nucleic Acids Res. 2003; 31: e72. [Abstract] [Full text] [Print PDF]  

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