Table 1 Increase in coverage of 6 representative proteomes over the past 9 years of Pfam

Release/Date No. Models E.coli K12 R.prowazekii M.jannaschii S.cerevisiae C.elegans H.sapiens

Protein coverage (%) 18.0 (07/2005) 7973 84 81 72 64 60 64
10.0 (07/2003) 6190 76 77 68 60 57 60
5.5 (09/2000) 2478 55 62 52 47 47 52
Residue coverage (%) 18.0 (07/2005) 7973 65 61 55 36 35 37
10.0 (07/2003) 6190 61 58 53 35 34 35
5.5 (09/2000) 2478 42 44 40 25 26 29

The models from releases 5.5, 10.0 and 18.0 were searched against each proteome, downloaded from Integr8 (http://www.ebi.ac.uk/integr8) (16). Every protein domain satisfying the curated Pfam gathering threshold cut-off was scored as a hit. Two different coverage measures have been included, protein coverage and residue coverage.