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Nucleic Acids Research, 1974, Vol. 1, No. 1 109-128
© 1974

Articles

Thermodynamic and kinetic properties of short RNA helices: the oligomer sequence AnGCUn

Jeffrey Ravetch, Jay Gralla and D.M. Crothers

Department of Chemistry, Yale University New Haven, Connecticut 06520

Received November 7, 1973. We studied the thermodynamic, kinetic and optical properties of the double helices formed by the series of self-complementary oli-gonucle otides, (Ap)n GpC(pU)n, 2 ≤ n ≤ 4, and found that the shortest helix, containing just 6 base pairs, is less stable than would be predicted from the properties of the larger molecules. It also shows a markedly smaller hyperchromism on melting than expected. These anomalous properties of a short helix indicate that one cannot always assume that base pair free energies and extinction coefficient changes are independent of helix size.


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