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Nucleic Acids Research, 1974, Vol. 1, No. 1 45-52
© 1974

Articles

The selective reaction of methoxyamine with cytidine residues in mammalian initiator transfer ribonucleic acid

Peter W. Piper and Brian F.C. Clark

Medical Research Council, Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, England

Received October 29, 1973. Methoxyamine reacts selectively with tRNA molecules at certain exposed cytosine residues usually located in non base-paired regions of the two dimensional clover leaf structure. Here methoxyamine is used for the first time in a study of a mammalian tRNA structure. One of the sequence abnormalities of myeloma initiator tRNA is a cytosine instead of the usual uracil immediately preceding the anticodon. A study of the reaction of the cytosine residues with methoxyamine indicates that the accessibility of bases to chemical reagents in the anticodon loop of this mammalian initiator tRNA is very similar to that observed for the bacterial initiator tRNA.


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