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Nucleic Acids Research, 1974, Vol. 1, No. 1 53-61
© 1974

Articles

Polynucleotides. XXII(1). Synthesis and properties of poly 7-deazainosinic acid

Morio Ikehara, Toshikazu Fukui, Toshiko Koide and Junko In aba

Faculty of Pharmaceutical Sciences, Osaka University 6-1-1, Toneyama, Toyonaka, Osaka, Japan

Received October 30, 1973. Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin and the nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer has similar physical properties to poly(I), but has alow thermal stability in the double-stranded complex with poly(C). Poly(7-deaza I), in contrast, forms a more stable triple-stranded complex with poly(A) than 2 poly (I) poly(A), presumably due to the higher pK value.


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