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Nucleic Acids Research, 1974, Vol. 1, No. 11 1399-1410
© 1974

Articles

Protection of avian myeloblastosis virus (AMV) DNA polymerase by substrates against heat inactivation

Takis S. Papas, Michael A. Chirigos and Jack G. Chirikjian*

Viral Biology Branch NCI, NIH, Bethesda, MD, USA *Georgetown School of Medicine and Dentistry Washington, DC 20007, USA

Received July 25, 1974. Purified DNA polymerase from AMV was exposed to thermal inactivation in the presence and absence of various compounds required for maximal activity. A synergistic protective effect was noted when all the components were present. The enzyme showed a distinct preference for primed templates, especially for its native 70S RNA. Heat inactivation studies also suggested that the active sites for RNase H and that for the polymerase were not identical.


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