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Nucleic Acids Research, 1974, Vol. 1, No. 11 1421-1438
© 1974

Articles

An RNA fraction in chromatin of L-929 cells associated with DNA

John J. Monahan and Ross H. Hall

Department of Biochemistry, McMaster University Medical Centre Hamilton, Ontario, Canada L8S 4J9

Received August 6, 1974. The DNA of L–929 cell nuclei was examined for the presence of an RNA fraction hybridized to the DNA that could possibly serve a role in gene regulation. A low molecular weight (~4.5S) RNA fraction was observed as an RNA-DNA complex in chromatin preparations subfractionated on a CS2SO4, density gradient. This RNA does not appear to be covalently attached to the DNA. Neither does it appear to be attached to the DNA via a protein component. The RNA is resistant to ribonuclease H but is slowly attached by ribonuclease A + T1. A role for, as well as the nature of the attachment of this RNA to DNA is suggested.


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