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Nucleic Acids Research, 1974, Vol. 1, No. 11 1531-1538
© 1974

Articles

Differences in the secondary structures of native and denatured yeast leucine transfer ribonucleic acid

Erin R. Hawkins and Simon H. Chang

Department of Biochemistry, Louisiana State University Baton Rouge, Louisiana 70803, USA

Received August 27, 1974. Structural differences between the native and denatured conformers of leucine tRNA3, from Baker's yeast were examined by a comparison of the susceptibility of the two forms to chemical modification by kethoxal. Two moles of kethoxal were initially incorporated by the native molecule at positions located in the highly exposed dihydrouridine loop. On the otherhand, nine guanosine residues were modified in the denatured conformer, including those in the dihydrouridine loop as well as residues in the dihydrouridine stem and the anticodon stem regions. Thus these regions are apparently no longer base-paired in the inactive, denatured conformer, and their importance in the biological function of the molecule is implicated.


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