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Nucleic Acids Research, 1974, Vol. 1, No. 11 1619-1630
© 1974

Articles

The synthesis of poly-4-thiouridylic acid and its effect on protein synthesis in a cell free system derived from rat liver

A.A. Hochberg and M. Keren-Zur

Department of Biological Chemistry, The Hebrew University Jerusalem, Israel

Received September 30, 1974. The synthesis of poly-4-thiouridylic acid by thiolation of poly-cytidylic acid is described. A quantitative thiolation was achieved without any cleavage of the phosphodiester bond. The inhibitory effect of the poly-4-thiouridylic acid on protein synthesis in a cell free system derived from rat liver was investigated.


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