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Nucleic Acids Research, 1982, Vol. 10, No. 11 3503-3515
© 1982

MOLECULAR BIOLOGY

Comparison of the nucleotide sequence of cloned human and guinea-pig pre-{alpha}-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene

Len Hall, Roger K. Craig*, Mark R. Edbrooke and Peter N. Campbell

Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School London W1P 7PN, UK

*To whom correspondence should be addressed

Received April 6, 1982. Revised May 13, 1982. Accepted May 13, 1982.

Nucleotide sequence analyses of essentially full-length copies of human and guinea-pig pre-{alpha}-lactalbumin cDNAs contained within recombinant plasmids, (i) confirm the presence of 19 amino acid hydrophobic amino terminal peptide extensions encoded within each mRNA; and (ii) provides evidence for the existence of a minor variant of guinea-pig {alpha}-lactalbumin mRNA encoding a protein with a 36 residue carboxyl-terminal extension. Comparison of the nucleotide sequence within the coding region of the human, and the predominant guinea-pig pre-{alpha}-lactalbumin mRNAs, with the analogous region of hen pre-lysozyme mRNA provides compelling evidence that all have evolved from a comwn ancestral gene.


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