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Nucleic Acids Research, 1982, Vol. 10, No. 11 3531-3539
© 1982


MOLECULAR BIOLOGY

Nucleotide sequence of a region of the mitochondrial genome of Aspergillus nidulans including the gene for ATPase subunit 6

E. Grisi*, T.A. Brown, R.B. Waring, C. Scazzocchio* and R.W. Davies+

Department of Biochemistry, University of Manchester Institute of Science and Technology P.O. Box 88, Manchester M60 IQD *Department of Biology, University of Essex Colchester C04 3SQ, UK

+Author to whom reprint requests should be sent

Received March 29, 1982. Accepted May 7, 1982.

A 1500 bp fragment of the Aspergillus nidulans mitochondrial genome contains genes for arginine and asparagine tRNAs, an unassigned reading frame, and the structural gene for ATPase subunit 6. The tRNA genes possess 66 nucleotide homology and possibly originated by a relatively recent duplication event. The unassigned reading frame displays a low level of homology with the human URF A6L. The predicted amino acid sequence of the A.nidulans ATPase subunit 6 gene is 40% homologous to the yeast polypeptide and includes the short, highly conserved regions also present in the equivalent subunits from other mitochondrial systems and from Escherichia coli.


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