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Nucleic Acids Research, 1982, Vol. 10, No. 12 3803-3816
© 1982

CHEMISTRY

Interaction of adriamycin with DNA as studied by resonance Raman spectroscopy

Michel Manfait1,*, Alain J.P. Alix1, Pierre Jeannesson2, Jean-Claude Jardillier2 and Théophile Theophanides3,*

1Lab. Recherches Optiques, Faculté des Sciences B.P. 347, 51062 Reims 2Lab. Biochimie, Faculté de Pharmacie 51096 Reims, and Inst. Anticancer, J.Godinot, Reims France 3Dép Chimie, Faculté des Arts et des Sciences C.P. 6210, Succ. A, Montreal, Québec, Canada H3C 3V1

*Authors to whom reprint request should be addressed

Received February 5, 1982. Revised May 26, 1982. Accepted May 25, 1982.

Raman and resonance Raman spectra of the complex DNA-adriamycin in aqueous solution have been recorded and analysed. Calf thymus DNA was used and it is found that in the complex DNA-adriamycin the chromophore of adriamycin is intercalated in the GC sequences. The substituents on the rings give hydrogen bonding interactions with the base pairs above and below the interca-lation site. It is suggested from the Raman and resonance Raman spectral modifications that the phenolic groups of the chro-mophore are involved in the drug-UNA intercalation, in addition to {Pi}–{Pi}, hydroxyl and amino interactions.


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