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Nucleic Acids Research, 1982, Vol. 10, No. 16 4873-4882
© 1982

MOLECULAR BIOLOGY

Isolation of the human HDL apoprotein A1 gene

Carol C. Shoulders and Francisco E. Baralle

Sir William Dunn School of Pathology, University of Oxford South Parks Road, Oxford OX1 3RE, UK

Received June 9, 1982. Accepted July 13, 1982.

Apo Al is the major apoprotein of the human plasma high density lipoprotein (HDL). We have isolated apu Al cDNA and genomic clones and used then to study the gene organisation as defined by its restriction enzyme map. These studies showed that apo Al is related by a unique gene. Cross hybridisation was not observed with functionally related a genes. Increased levels of HDL have been currelated with certain protection against coronary heart disease. If there is a genetic component that contributes to the variable levels of HDL found in the population, it may be possible to correlate these differences with distinct gene organisaticn patterns.


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