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Nucleic Acids Research, 1982, Vol. 10, No. 16 4973-4983
© 1982

CHEMISTRY

NMR evidence for the existence of two native conformations of 5S RNA

M.J. Kime and P.B. Moore

Department of Chemistry, Yale University P.O. Box 6666, New Haven, CT 06511, USA

Received May 14, 1982. Revised July 6, 1982. Accepted July 6, 1982.

NMR spectra of the non-exchangeable protons in 5S RNA from E. coli show the existence of two distinct conformers of the molecule which meet the operational definition of "A form" or native 5S RNA. Both are easily distinguished spectroscopically from denatured, "B form" 5S RNA. The conditions which interconvert the two A form conformers strongly suggest that the transition between them gives rise to the low temperature optical melting transition first reported in 5S RNA by Kao and Crothers (l).


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