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Nucleic Acids Research, 1982, Vol. 10, No. 16 5073-5084
© 1982

ENZYMOLOGY

Increased activity of polynucleotide ligase in 5-iodo-2'-deoxyuridine and mitomycin C-pretreated simian virus 40 (SV40)-infected monkey kidney cells

M. Mezzina, H.G. Suarez, R. Cassingena and A. Sarasin

Institut de Recherches Scientifiques sur le Cancer B.P. 8,94802 Villejuif Cedex, France

Received April 7, 1982. Revised June 28, 1982. Accepted July 26, 1982.

The DNA ligase activity has been studied in 5-iodo-2'-deoxyuridine (IUdR), mitomycin C (MMC) and IUdR+MMC-treated SV40-infected or mock-infected CV1C11 monkey kidney cells. The results have shown that: 1. The level of enzyme activity is about two or three times higher in IUdR or MMC-treated non-infected cells; 2. SV40 infection doubles the level of ligase activity in the untreated cells; 3. There is an additional increase of ligase activity in IUdR or MMC-treated SV40-infected cells; 4. When infected or mock-infected cells are treated with IUdR+MMC, there is no modification of the results obtained with each drug alone; 5. Two peaks of different S values are detected in a partial purification of the drug(s) or viral induced enzyme(s).


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