Nucleic Acids Research, 1982, Vol. 10, No. 24 7895-7903
© 1982
MOLECULAR BIOLOGY |
Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line
Laboratoire de Geèneètique Mole`culaire des Eucaryotes du CNRS, Uniteè 184 de Biologie Moleèculaire et de Geènie Geèneètique de I'INSERM, Faculteè de Meèdecine 11 Rue Humann, 67085 Strasbourg Ceèdex, France
*to whom reprint requests should be sent
Received November 18, 1982. Accepted November 25, 1982.
cDNA clones corresponding to a mRNA whose level is rapidly increased by addition of oestradiol to the culture medium have been isolated by differential screening of a cDNA library from the breast cancer cell line MCF-7, which contains oestrogen receptors. Such clones will be useful in studies of the DNA sequences required for hormonal induction and to determine whether expression of the corresponding gene is in any way related to the cancerous state. We have also obtained a cDNA clone for a messenger whose level is apparently decreased by steroid hormones
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