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Nucleic Acids Research, 1982, Vol. 10, No. 24 7935-7945
© 1982

MOLECULAR BIOLOGY

The organization of the tadpole and adult {alpha} globin genes of Xenopus laevis

Roger K. Patient+, Denis Banville*, Alison C. Brewer+, Jane A. Elkington*, David R. Greaes+, Malgorzata M. Lloyd* and Jeffrey G. Williams*

+King's College, Department of Biophysics, 26-29 Drury Lane London WC2B 5RL *Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane London NW7 IAD UK

Received November 1, 1982. Accepted November 12, 1982.

Adult erythrocytes of X. laevis contain six electrophoretically resolvtides globin polypeptides while tadpole erythrocytes contain four polypeptides, none of which comigrates which an adult protein. We show that three of the adult proteins are {alpha} globin polypeptides (A {alpha}2, {alpha}3) and three are ß qlobin polypeptides (ß1, ß2, ß3). We find that a tadpole {alpha} globin gene ({alpha}T1) is linked to the major adult locus in the sequences 5‘-{alpha}T1-{alpha}2-ß2-3‘ with 5.2 kb separating {alpha}T1 from {alpha}1. Another tadpole {alpha} globin gene ({alpha}T2) is linked to the minor adult locus in the sequence 5‘-{alpha}T2-{alpha}2-ß2-3‘ with 10.7 kb separating {alpha}T2 from {alpha}2. These linkage relationships are consistent with the major and minor loci having arisen by tetraploidization but the different separation of larval and adult globin genes at the two loci indicates the occurrence of some additional chromosomal rearrangement. Two alternative models are presented.


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