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Nucleic Acids Research, 1982, Vol. 10, No. 24 8049-8059
© 1982

MOLECULAR BIOLOGY

Histone H4 hyperacetylation and rapid turnover of its acetyl groups in transcriptionally inactive rooster testis spermatids

R. Oliva and C. Mezquita

Department of Fisiologiá, Facultad de Medicina, Universidad de Barcelona, Casanova 143 Barcelona-36, Spain

Received October 22, 1982. Accepted November 24, 1982.

In order to study the relationship between acetylation of histones, chromation structure and gene activity, the distribution and turnover of acetyl groups among nucleosomal core histones and the extent of histone H4 acetylation were examined in rooster testis cell nuclei at different stages of spermatogenesis. Histone H4 was the predominant acetylated histone in mature testes. Hyperacetylation of H4 and rapid turnover of its acetyl groups are not univocally correlated with transcriptional activity since they were detected in both genetically active testicular cells and genetically inactive elongated spermatids. During the transition from nucleohistone to nucleprotamine in elongated spermatids the chromatin undergoes dramatic structural changes with exposition of binding sites on DNA (1). Hyperacetylation of H4 and rapid turnover of its acetyl groups could be correlated with the particular conformation of chromatin in elongated spermatids and might represent a necessary condition for binding of chromosomal proteins to DNA.


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