Skip Navigation

This Article
Right arrow Print PDF (524K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Hayward, M. A.
Right arrow Articles by Shapiro, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayward, M. A.
Right arrow Articles by Shapiro, D. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1982, Vol. 10, No. 24 8273-8284
© 1982

MOLECULAR BIOLOGY

Activation of vitellogenin gene transcription is a direct response to estrogen in Xenopus laevisliver*

Marshall A. Hayward, Martin L. Brock and David J. Shapiro

Department of Biochemistry, University of Illinois W. California, Urbana, IL61801, USA

Received October 5, 1982. Accepted November 10, 1982.

Estrogen induces the synthes is of vitellogenin mRNA by activating transcription of the vitellogenin genes. Quantitative inhibition of 1iver protein synthesis by cycloheximide does not prevent activation of vitellogenin gene transcription. The relative transcription rate of the vitellogenin genes in estrogen stimulated liver is similar in control and cycloheximide treated animals (800-1000ppm). Selective estrogen activation of vitellogenin gene transcription therefore represents a direct effect of estrogen on vitellogenin gene transcription which can occur without any change in the cells' protein complement. Two other cellular responses to estrogen, the induction of nuclear estrogen receptor, and an increased rate of total nuclear RNA synthesis, are blocked by cycloheximide administration. Since the overall rate of vitellogenin mRNA synthesis is a function of both the selective estrogen activation of vitellogenin gene transcription which is not blocked by cycloheximide and the increased rate of total nuclear RNA synthesis which is blocked by cycloheximide, the total rate of vitellogenin mRNA synthesis is markedly reduced following cycloheximide administration.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
W.-J. Welboren, F. C G J Sweep, P. N Span, and H. G Stunnenberg
Genomic actions of estrogen receptor {alpha}: what are the targets and how are they regulated?
Endocr. Relat. Cancer, December 1, 2009; 16(4): 1073 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. S. Edinger, E. Mambo, and M. I. Evans
Estrogen-Dependent Transcriptional Activation and Vitellogenin Gene Memory
Mol. Endocrinol., December 1, 1997; 11(13): 1985 - 1993.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Lee and J. Gorski
Estrogen-induced transcription of the progesterone receptor gene does not parallel estrogen receptor occupancy
PNAS, December 24, 1996; 93(26): 15180 - 15184.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B Corthesy, R Hipskind, I Theulaz, and W Wahli
Estrogen-dependent in vitro transcription from the vitellogenin promoter in liver nuclear extracts
Science, March 4, 1988; 239(4844): 1137 - 1139.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.