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Nucleic Acids Research, 1982, Vol. 10, No. 24 8285-8295
© 1982

MOLECULAR BIOLOGY

Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus

A. J. Makoff*, C. A. Paynter*, D. J. Rowlands+ and J. C. Boothroyd*,§

+Department of Biochemistry, Animal Virus Research Institute Pirbright, Woking, Surrey GU24 0NF, UK *Department of Molecular Biology (formerly Immunochemistry), Wellcome Research Laboratories Lengley Court, Beckenham, Kent BR3 3BS, UK

Received September 29, 1982. Accepted November 16, 1982.

Cloned cDNA molecules from three serotypes of FMDV have been sequenced around the VP1-coding region. The predicted amino acid sequences for VP1 were compared with the published sequences and variable regions identified. The amino acid sequences were also analysed for hydrophilic regions. Two of the variable regions, numbered 129-160 and 193-204 overlapped hydrophilic regions, and were therefore identified as potentially immunogenic. These regions overlap regions shown by others to be immunogenic.

§Present address: Department of Medical Microbiology, Stanford University, Stanford, CA 94305, USA


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