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Nucleic Acids Research, 1982, Vol. 10, No. 3 1071-1080
© 1982

CHEMISTRY

A Z-like form of poly(dA-dC).poly(dC-bT) in sotation?

Michaela Vorlícková, Jaroslav Kypr, Stepáanka Stokrová1 and Jaroslav Sponar2

Institute of Biophysics, Czechoslovak Academy of Sciences 612 65 Brno, Czechoslovakia 1Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences 162 06 Prague, Czechoslovakia 2Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences 166 10 Prague, Czechoslovakia

Received November 24, 1981. Accepted January 4, 1982.

Circular dichroism was used to study change in conformation of poly (dA-dC).poly(dG-dT) caused by a high concentration of various monovalent salts. It was found that CsF induced the gradual appearance of a negative band in the long wavelength part of the CD spectrum of poly(dA-dC).poly(dG-dT) which might reflect a transition of this DNA toward a Z-like structure.


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C Gaillard and F Strauss
Association of poly(CA).poly(TG) DNA fragments into four-stranded complexes bound by HMG1 and 2
Science, April 15, 1994; 264(5157): 433 - 436.
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