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Nucleic Acids Research, 1982, Vol. 10, No. 3 1081-1091
© 1982

CHEMISTRY

Conformational transitions of poly(dA-dC).poly(dG-dT) induced by high salt or in ethanolic solution

Christoph Zimmer*, Sylvie Tymen+, Christian Marck+,{dagger} and Wilhelm Guschlbauer+

*Akad. Wiss. DDR, Zentralinstitut für Mikrobilogie und Experimentelle Therapie, Jena, Abt. Molekulare Biochemie, DDR 6900-Jena, Beutenbergstr. 11, GDR +Service de Biochimie, Département der Biologie, Centre d'Etudes Nucléaires de Saclay, F-91191 Gif-sur-Yvette, France

{dagger}To whom correspondence should be addressed

Received November 16, 1981. Accepted January 4, 1982.

Poly(dA-dC)·poly(dG-dT) was studied by circular dichroism in the presence of high CaCl concentrations and in ethanolic solutions. This alternating purine-pyrimidine duplex may undergo two conformational transitions from a B-type to a novel structure and subsequently into an A-form. Cs+ ions or increasing ethanol concentrations induced a change of the B-type CD spectrum and an inversion of the long wavelength CD band. Lowering the temperature below 0°C or addition of small amounts of Ca++ ions were particularly potent in producing a large negative CD band. A modified B-type structure or a conversion into a left-handed Z-form is considered for this conformational transition.


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C Gaillard and F Strauss
Association of poly(CA).poly(TG) DNA fragments into four-stranded complexes bound by HMG1 and 2
Science, April 15, 1994; 264(5157): 433 - 436.
[Abstract] [PDF]


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