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Nucleic Acids Research, 1982, Vol. 10, No. 3 1127-1145
© 1982

MOLECULAR BIOLOGY

Rearrangements of DNA-protien interactions in animal cells coupled with growth quiescence transitions

Anatoly V. Lichtenstein, Nikolai I. Sjakste, Mikhail M. Zaboykin and Vladimir S. Shapot

All-Union Oncological Scientific Centre Moscow 115478, USSR

Received September 10, 1981. Revised December 3, 1981. Accepted January 5, 1982.

Overall DNA-protein Interactions in animal cells undergodrastic changes coupled with cellular transitions from quiescence to growth and reversely as revealed by nucleoprotein-Celite chromatography.DNA of chromatin was found to exist in one of the two sharply distinct alternative forms, namely, either tightly or weakly bound to protein moiety. These forms are specific for cycling and quiescent cells, respectively. The tight DNA-protein interactions characterize all cycling cells independent of the cell cycle phase. Transition of DNA of cycling cells from one form to another was observed as a result of treatment of isolated nuclei with DNase I.


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