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Nucleic Acids Research, 1982, Vol. 10, No. 5 1459-1469
© 1982

MOLECULAR BIOLOGY

Structural analysis of repetitive DNA sequences in the bovine corticotropin-ß-tipotropin precursor gene region

Yumiko Watanabe*, Toshihiko Tsukada*,+, Mitsue Notake*, Shigetada Nakanishi{dagger} and Shosaku Numa*

*Department of Medical Chemistry, Kyoto University Faculty of Medicine Kyoto 606, Japan +Second Division, Department of Internal Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan {dagger}Institute for Immunology, Kyoto University Faculty of Medicine Kyoto 606, Japan

Received January 6, 1982. Accepted February 1, 1982.

Repetitive DNA sequences in the bovine corticotropin-ß-lipotropin precursor gene region have been mapped and subjected to nucleotide sequence analysis. Two of the four repetitive DNA segments found are located in the 5'-flanking region, and one each within the intervening sequences. Each repetitive DNA segment contains one to three highly homologous unit sequences with an approximate length of 120 base pairs. All the unit sequences are flanked on the 3' side by tandem repeats. There are about 105 copies of the repetitive DNA in the bovine genome. Comparison of the bovine repetitive sequences with those of other mammalian species reveals the presence of a homologous segment of approximately 40 base pairs. This segment and the region preceding it in the bovine repetitive DNA exhibit sequence homology with the region encompassing the origin of DNA replication in papovaviruses.


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