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Nucleic Acids Research, 1982, Vol. 10, No. 5 1471-1479
© 1982

MOLECULAR BIOLOGY

Repetitive DNA sequences in the human corticotropin-ß-lipotropin precursor gene region: Alu family members

Toshihiko Tsukada*,+, Yumiko Watanabe*, Yoshikatsu Nakai+, Hiroo Imura+, Shigetada Nakanishi{dagger} and Shosaku Numa*

*Department of Medical Chemistry, Kyoto University Faculty of Medicine Kyoto 606, Japan +Second Division, Department of Internal Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan {dagger}Institute for Immunology, Kyoto University Faculty of Medicine Kyoto 606, Japan

Received January 6, 1982. Accepted February 1, 1982.

Repetitive DNA sequences in the bovine corticotropin-ß-lipotropin precursor gene region have been studied by blot hybridization analysis and DNA sequencing. Six repetitive sequences are present in this gene region; five of them are Alu family members with an approximate length of 300 base pairs, and the other consists of a portion of an Alu family sequence. Two of these Alu family members are located in the 5'-flanking region of the gene, and the remaining four within the intervening sequences. These Alu family sequences constitute inverted repeats in the intervening sequences as well as in the 5'-flanking region of the gene.


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