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Nucleic Acids Research, 1982, Vol. 10, No. 5 1707-1720
© 1982

CHEMISTRY

Recognition of base pairs by polar peptides in double stranded DNA

Alain Laigle, Laurent Chinsky and Pierre-Yves Turpin

Institut Curie, Section de Physique et Chimie 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France

Received January 26, 1982. Accepted February 8, 1982.

The resonance Raman spectrum of native DNA has been obtained using excitation at 257 nm. In a first part, the spectral lines are assigned to the different nucleotide bases which provide the resonance effect. In a second part, the interactions of DNA with basic peptides (Arginine Methylester, Lysine Methylester, Arginyl-arginine) are investigated using excitation at 300 nm and 257 nm, which give complementary information about the DNA. Both Arginine Methylester and Arginyl-arginine recognize the A-T base pairs, the first one in the large groove, the second one in the narrow groove of DNA. The DNA-Lysine Methylester interaction is very likely not specific but can take place in the large groove of DNA.


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