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Nucleic Acids Research, 1982, Vol. 10, No. 6 2135-2143
© 1982

MOLECULAR BIOLOGY

Nucteotide sequence of human influenza A/PR/8/34 segment 2

Greg Winter and Stan Fields*

MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK

Received January 25, 1982. Accepted February 26, 1982.

The nucleotide sequence of RNA segment 2 of human influenza strain A/PH/8/34 has been determined. Segnent 2 is 2341 nucleotides long and encodes a protein of 757 amino acids (86,500 daltons molecular weight) which is involved in RNA synthesis. Although segment 2 is identical in size to segment 1, which encodes a protein of related function, neither the nucleotide sequences of these two RNA segments nor the amino acid sequences of the encoded proteins appear to be homologous. The sequence of segment 2 completes the sequence of the virus (total 13,588 nucleotides).

*Present address: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA


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