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Nucleic Acids Research, 1982, Vol. 10, No. 7 2225-2240
© 1982

MOLECULAR BIOLOGY

Variation in the sequence and modification state of the human insulin gene flanking regions

Axel Ullrich*, Thomas J. Dull1, Alane Gray1, John A. Philips, III2 and Stephan Peter3

1Genentech Inc. 460 Pt. San Bruno Blvd., South San Francisco, CA 94080 2Johns Hopkins University, Department of Pediatrics, School of Medicine Baltimore, MD 21205, USA 3Department of Urology, Mannheim, University of Heidelberg D-6900 Heidelberg, FRG

*To whom repnnt requests should be sent

Received February 16, 1982. Accepted March 12, 1982.

The nucleotide sequence of a highly repetitive sequence region upstream from the htisan insulin gene is reported. The length of this region varies between alleles in the population, and appears to be staoly transmitted to the next generation in a Mendelian fashion. There is no significant correlation between the length of this sequence and two types of diabetes mellitus. We observe variation in the cleavability of a Bgll recognition site downstream from the human insulin gene, which is probably due to variable nucleotide modification. This presumed modification state appears not to be inherited, and varies between tissues within an individual and between individuals for a given tissue. Both alleles in a given tissue DNA sample are modified to the same extent.


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