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Nucleic Acids Research, 1982, Vol. 10, No. 7 2241-2256
© 1982

MOLECULAR BIOLOGY

Detailed structural analysis of two spliced HSV-1 immediate-early mRNAs

Frazer J. Rixon and J.Barklie Clements

institute of Virology, University of Glasgow Glasgow G11 5JR, UK

Received February 15, 1982. Accepted March 17, 1982.

The structuree of two HSV-1 immediate-early mRNAs have been determined by nuclease-digestion procedures using 5' and 3' end-labelled DNA probes. These mRNAs, which map across the junctions between the short unique (Us and short repeat (IRs and TRs genome regions, have common 5' portions located in IRs and TRs The 3' portions, which extend into opposite ends of Us are unique. The DNA sequence encoding the common 5' portions largely comprises a 247 base pair (bp) leader region and a single intron of variable size. The variation in intron length is due to different copy numbers of a 22 bp tandem reiteration. A small proportion of the mRNA population is unspliced, but otherwise is identical to the more abundant spliced species.


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