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Nucleic Acids Research, 1982, Vol. 10, No. 8 2677-2684
© 1982


MOLECULAR BIOLOGY

Mouse whey acidic protein is a novel member of the family of ‘four-disulfide core’ proteins

Lothar G. Hennighausen and Albrecht E. Sippel

Institut für Genetik, University of Cologne Weyertal 121, 5000 Köln 41, FRG

Received February 22, 1982. Revised March 23, 1982. Accepted March 23, 1982.

Unlike in other mammalian species, the major whey protein in mouse is not {alpha}-lactalbumin, but a cysteine rich, acidic protein with a molecular weight of 14.0 kDa. We have deduced the amino acid sequence of this mouse acidic whey protein from the nucleotide sequence of cloned cDNA. The positions of the half cysteines suggest that mouse whey acidic protein (WAP) is a two domain protein, very similar in structure to the plant lectin wheat germ agglutinin and the hypothalamic carrier protein neurophysin.


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