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Nucleic Acids Research, 1983, Vol. 11, No. 1 91-104
© 1983

MOLECULAR BIOLOGY

Chick pro{alpha}2 (I) collagen gene; exon location and coding potential for the prepropeptide

Valerie E. Tate, Mitchell H. Finer, Helga Boedtker and Paul Doty

Department of Biochemistry and Molecular Biology, Harvard University 7 Divinity Avenue, Cambridge, MA 02138, USA

Received September 29, 1982. Revised November 29, 1982. Accepted November 29, 1982.

We report the DNA sequence of a cDNA clone complementary to the 5' end of the chick pro{alpha}2(I) mRNA. The sequence enables us to deduce the and no acid sequence of this region, which has been refractory to conventional protein sequencing techniques. Its importance lies in the role of the prepropeptide in secretion, triple helix formation of the mature protein and initiation of flbrillogenesis. We have also located four of the five exons which code for this region on the genome. One exon is only llbp in size and appears to code exclusively for the signal propeptidase cleavage site. This is an extreme example of an exon defining a functional unit.


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