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Nucleic Acids Research, 1983, Vol. 11, No. 12 3855-3861
© 1983

MOLECULAR BIOLOGY

Nucleotide sequences within the cholera toxin operon

Maria L. Gennaro and Peter J. Greenaway+

Department of Medical Bacteriology and Mycology, Istituto Superiore di Sanita Viale Regina, 00161 Roma, Italy +Molecular Genetics Laboratory, PHLS Centre for Applied Microbiology and Research Porton Down, Salisbury, Wiltshire SP4 0JG, UK

Received April 29, 1983. Accepted May 27, 1983.

Nucleotide sequences coding for the N- and C-terminus of the A subunit and the N-terminus of the B subunit of cholera toxin were determined. These results show that the genes for the A and B subunits overlap out of phase by one nucleotide and that each subunit is synthesised as a precursor molecule which is subsequently processed after translation. It is proposed that the synthesis of each subunit is regulated at the translational level. Considerable homology with the heat labile toxin genes of enteropathogenic E.coli was noted.


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