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Nucleic Acids Research, 1983, Vol. 11, No. 12 4141-4155
© 1983

CHEMISTRY

Heteronomous DNA

Struther Arnott*, R. Chandrasekaran, I.H. Hall and L.C. Puigjaner

Department of Biological Sciences, Purdue University West Lafayette, IN 47907, USA

*To whom correspondence should be sent

Received February 8, 1983. Revised April 27, 1983. Accepted April 27, 1983.

A fibrous form of poly d(A):poly d(T) has a heteronomous secondary structure which is the first to be confirmed for a polynucleotide duplex: although both chains are 101 helices, mutually hydrogen-bonded in the standard (Watson-Crick) fasnion, each has a quite different conformation. One chain -- probably poly d(A) -- has C3'-endo-puckered furanose rings characteristic of the A family of polynucleotide secondary structures while the other -- probably poly d(T) -- has the C2'-endo-puckered rings of the B family. Since analogous heteronomous structures could be assumed by DNA-DNA or DNA-RNA duplexes containing more general base sequences the polymorphic range of polynucleotide double-helices may be even greater than we have come to suppose.


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