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Nucleic Acids Research, 1983, Vol. 11, No. 15 5055-5071
© 1983

MOLECULAR BIOLOGY

The complete nucleotide sequence of the I-E{alpha}d immune response gene

Jens Jörgen Hyldig-Nielsen*, Lena schenning, Ulf Hammerling, Eva Widmark, Eva Heldin, Peter Lind, Bo Servenius, Torben Lund1,+, Richard Flavel1,+, Janet S. Lee2, John Trowsdale2, Peter H. Schreier3, Fred Zablitzky3, Dan Larhammar, Per A. Peterson and Lars Rask

Department of Cell Research, The Wallenberg Laboratory, University of Uppsala, Box 256, 751 22 Uppsala, Sweden 1Laboratory of Gene strucutre and Expression, National Institute of Medical Research Mill Hill 2Imperial Cancer Research Fund Lincoln's Inn fields, London ,UK 3Department of Genetics, Univeristy of Cologne Cologne, FRG

*To whom correspondence should be addressed.

Received June 9, 1983. Accepted July 7, 1983.

We have isolated and sequenced the complete muring I-Ea immune response gene of the H-2a haplotype. The I-Ea gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the a chain. The amino acid sequence deduced from the I-Ea gene shows 75% homology to its human counterpart, the HLA-DR a chain. The absence of I-E antigen in H-2a mice is due to lack of Ea chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-Eabgene.

+Present address: Biogen Inc., 241, Binney Street, Cambridge, MA, USA.


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