Skip Navigation

This Article
Right arrow Print PDF (489K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (44)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Golankiewicz, B.
Right arrow Articles by Folkman, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Golankiewicz, B.
Right arrow Articles by Folkman, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1983, Vol. 11, No. 15 5243-6255
© 1983

CHEMISTRY

Methylation of desmethyl analogue of Y nucleosides. Wyosine from guanosine

Bozenna Golankiewicz and Wojciech Folkman

Institute of Bioorganic Chemistry, Polish Academy of Sciences Noskowskiego 12/14, 61–704 Poznan, Poland

Received June 10, 1983. Accepted July 4, 1983.

Wyoslne la. one of the fluorescent hypermodified Y nucleosides found In tRNAsPhe, was synthesized chemically from its biogenetic precursor guanosine 2. The route involved transformation of 2. into the tricyclic structure 3a and subsequent methylation at N-4. The major products of various methylation procedures were isomers of wyosine, methylated at H-5 (5b) or at H-l (4). Mesoionic compound 4 is a new analogue of 7-methylguanosine 5, modified nucl-eoside occuring in the unique positions in transfer, messenger and ribosomal HNAs. The chromatographio and spectral ohaxacteristios of wyosine and its isomers is given.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.